Assistant Research Professor of Chemistry

Pennsylvania State University

Assistant Research Professor
Penn State University

Campus/Location:University Park Campus
Campus City:University Park, PA
Date Announced:01/17/2020
Date Closing:open until filled
Job Number:93060
Work Unit:Eberly College of Science

The laboratory of Stephen Benkovic in the Chemistry Department, at The Pennsylvania State University, seeks to fill an Assistant Research Professor position with a highly motivated candidate. The position requires a Ph.D. in biochemistry, chemical biology, or related field and 5 years of postdoctoral experience. The candidate should possess extensive experience in metabolic enzymology with particular emphasis on intracellular fluorescence microscopy and protein-protein interaction reporter assays to define the assembly and operation of metabolons in cells. With our discovery of the purinosome, a metabolon that is constituted from the six enzymes in the de novo purine biosynthetic pathway, we now ask questions about what other metabolic pathways operate through condensed phase metabolons and whether they are proximal to one another in a cell. We will build upon our identification of protein-protein interactions within the purinosome metabolon or with proteins in other metabolic pathways to design and synthesize molecules to inhibit such associations. We will develop two hybrid based screens to identify specific protein -protein interactions for targeting with small molecules. Such molecules may be elaborated into drugs to alter metabolic diseases. The individual should be highly motivated and knowledgeable of relevant literature, be able to lead their own individual projects, write grants, and contribute to collaborative research efforts. Applications must be submitted electronically and include a CV with a list of publications, a cover letter describing their research interests, and the names of three references. Review of applicants will begin immediately and continue until the position is filled. This is a non-tenure track Fixed-Term appointment funded for one year from the date of hire with an excellent possibility of renewal.