Doctoral Position in Development of High Affinity Binders for Protein Purification

Royal Institute of Technology School of Engineering Sciences in Chemistry, Biotechnology and Health

Doctoral Position in Development of High Affinity Binders for Protein Purification

School of Engineering Sciences in Chemistry, Biotechnology and Health at KTH

KTH Royal Institute of Technology in Stockholm has grown to become one of Europe’s leading technical and engineering universities, as well as a key centre of intellectual talent and innovation. We are Sweden’s largest technical research and learning institution and home to students, researchers and faculty from around the world. Our research and education covers a wide area including natural sciences and all branches of engineering, as well as architecture, industrial management, urban planning, history and philosophy.

Project description

Third-cycle subject: Biotechnology

The focus of the research performed at the department is to develop predictable and robust systems for protein production, purification and detection. Well-characterized, small and folded domains descending from the bacterial receptors staphylococcal protein A (SPA) or streptococcal protein G (SPG) are used as scaffolds. Their known three-dimensional structures, a capability of independent folding and the absence of disulfide bridges make these domains ideal as frameworks for further protein engineering. Protein-engineering strategies are used in order to custom-make proteins for protein purification processes. Furthermore, high throughput methods for production and purification of proteins are developed. Depending on protein and aim we are using either mammalian cells or bacteria for the protein production.

We now look for a highly motivated doctoral student, to be engaged in a project that focuses on purification of biologicals. Within this project we aim to develop affinity proteins able to specifically bind to chosen target proteins. The new binders will be developed for the use in affinity protein purification to achieve robust, effective and efficient protein purification methods for different important target molecules. The project is part of a center (AdBIOPRO) with a focus on the production and purification of biologicals and will be run in close collaboration with the  industrial partners of the center.

Supervision: The doctoral student will be placed at the Royal Institute of Technology and professor Sophia Hober is proposed to supervise the doctoral student. Decisions are made on admission

What we offer

Admission requirements

To be admitted to postgraduate education (Chapter 7, 39 § Swedish Higher Education Ordinance), the applicant must have basic eligibility in accordance with either of the following:

  • passed a second cycle degree (for example a master's degree), or
  • completed course requirements of at least 240 higher education credits, of which at least 60 second-cycle higher education credits, or
  • acquired, in some other way within or outside the country, substantially equivalent knowledge

In addition to the above, there is also a mandatory requirement for English equivalent to English B/6, read more here


In order to succeed as a doctoral student at KTH you need to be goal oriented and persevering in your work. During the selection process, candidates will be assessed upon their ability to:

  • independently pursue his or her work
  • collaborate with others,
  • have a professional approach and
  • analyse and work with complex issues.

Applicants must be strongly motivated for doctoral studies, and have a strong interest in biotechnology and its applications. After the qualification requirements, great emphasis will be placed on personal competency. 

Target degree: Doctoral degree

Information regarding admission and employment

Only those admitted to postgraduate education may be employed as a doctoral student. The total length of employment may not be longer than what corresponds to full-time doctoral education in four years ' time. An employed doctoral student can, to a limited extent (maximum 20%), perform certain tasks within their role, e.g. training and administration. A new position as a doctoral student is for a maximum of one year, and then the employment may be renewed for a maximum of two years at a time.

Union representatives

You will find contact information for union representatives on KTH's website.

Doctoral section (Students’ union on KTH Royal Institute of Technology)

You will find contact information for doctoral section on the section's website.


Apply for the position and admission through KTH's recruitment system. It is the applicant’s responsibility to ensure that the application is complete in accordance with the instructions in the advertisement.

Applications must be received at the last closing date at midnight, CET/CEST (Central European Time/entral European Summer Time).

Applications must include the following elements:

  • CV including your relevant professional experience and knowledge.
  • Application letter with a brief description of why you want to pursue research studies, about what your academic interests are and how they relate to your previous studies and future goals. (Maximum 2 pages long)
  • Copies of diplomas and grades from previous university studies and certificates of fulfilled language requirements (see above). Translations into English or Swedish if the original document is not issued in one of these languages.Copies of originals must be certified.
  • Representative publications or technical reports. For longer documents, please provide a summary (abstract) and a web link to the full text.

Other information

Striving towards gender equality, diversity and equal conditions is both a question of quality for KTH and a given part of our values.

For information about processing of personal data in the recruitment process please read here.

We firmly decline all contact with staffing and recruitment agencies and job ad salespersons.

Disclaimer: In case of discrepancy between the Swedish original and the English translation of the job announcement, the Swedish version takes precedence.

Type of employment Temporary position longer than 6 months
Contract type Full time
First day of employment According to agreement
Salary Monthly salary according to KTH's doctoral student salary agreement
Number of positions 1
Full-time equivalent 100%
City Stockholm
County Stockholms län
Country Sweden
Reference number C-2022-2374
Sophia Hober, +46(8)7908794
Published 10.Nov.2022
Last application date 09.Dec.2022 11:59 PM CET
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