Doctoral Student in Development of Protein-Based Binders for Medical Purposes

Royal Institute of Technology

Doctoral student: development of protein-based binders for medical purposes

KTH Royal Institute of Technology

KTH Royal Institute of Technology in Stockholm has grown to become one of Europe’s leading technical and engineering universities, as well as a key centre of intellectual talent and innovation. We are Sweden’s largest technical research and learning institution and home to students, researchers and faculty from around the world. Our research and education covers a wide area including natural sciences and all branches of engineering, as well as architecture, industrial management, urban planning, history and philosophy.

Project description

Third-cycle subject: Biotechnology

The focus of the research performed at the department is to develop predictable and robust systems for protein production, purification and detection. Well-characterized, small and folded domains descending from the bacterial receptors staphylococcal protein A (SPA) or streptococcal protein G (SPG) are used as scaffolds. Their known three-dimensional structures, a capability of independent folding and the absence of disulfide bridges make these domains ideal as frameworks for further protein engineering. Protein-engineering strategies are used in order to custom-make proteins for protein purification processes. The designed purification tags and antibodies produced within the HPA program are combined to develop strategies for capture of proteins and protein complexes in an efficient and selective manner. Also binding proteins for use in cancer diagnostics as well as therapeutics have been designed and are now optimized to achieve high selectivity and specificity in vivo. Furthermore, high throughput methods for production and purification of proteins are developed. Depending on protein and aim we are using either mammalian cells or bacteria for the protein production. (https://www.kth.se/profile/sophia/page/the-hober-lab)

We now look for a highly motivated doctoral student, to be engaged in an ongoing project. Within this project we aim to develop an affinity protein-platform for selection and characterization of affinity proteins. The new binders will be utilized for different purposes. The first aim is to develop robust, effective and efficient protein purification methods for different important target molecules. The other aim is to develop therapeutic protein domains that can be tailored to specifically bind disease-causing proteins. 

Supervision: The doctoral student will be supervised by: professor Sophia Hober

What we offer

Eligibility

To be admitted to postgraduate education (Chapter 7, 39 § Swedish Higher Education Ordinance), the applicant must have basic eligibility in accordance with either of the following:

  • passed a degree at advanced level,
  • completed course requirements of at least 240 higher education credits, of which at least 60 higher education credits at advanced level, or
  • in any other way acquired within or outside the country acquired essentially equivalent knowledge.
  • Requirements for English equivalent to English B/6, read more here.

Selection

In order to succeed as a doctoral student at KTH you need to be goal oriented and persevering in your work. During the selection process, candidates will be assessed upon their ability to:

  • independently pursue his or her work
  • collaborate with others,
  • have a professional approach and
  • analyse and work with complex issues.
  • Applicants must be strongly motivated for doctoral studies, and have a strong interest in biotechnology and its applications within the biomedical field.

After the qualification requirements, great emphasis will be placed on personal qualities and personal suitability.

Target degree: Doctoral degree

Information regarding admission and employment

Only those admitted to postgraduate education may be employed as a doctoral student. The total length of employment may not be longer than what corresponds to full-time doctoral education in four years ' time. An employed doctoral student can, to a limited extent (maximum 20%), perform certain tasks within their role, e.g. training and administration. A new position as a doctoral student is for a maximum of one year, and then the employment may be renewed for a maximum of two years at a time.

Union representatives

You will find contact information for union representatives on KTH's website.

Doctoral section (Students’ union on KTH Royal Institute of Technology)

You will find contact information for doctoral section on the section's website.

Application

Apply for the position and admission through KTH's recruitment system. It is the applicant’s responsibility to ensure that the application is complete in accordance with the instructions in the advertisement.

Applications must be received at the last closing date at midnight, CET/CEST (Central European Time/entral European Summer Time).

Applications must include the following elements:

  • CV including your relevant professional experience and knowledge.
  • Application letter with a brief description of why you want to pursue research studies, about what your academic interests are and how they relate to your previous studies and future goals. (Maximum 2 pages long)
  • Copies of diplomas and grades from previous university studies and certificates of fulfilled language requirements (see above). Translations into English or Swedish if the original document is not issued in one of these languages.
  • Representative publications or technical reports. For longer documents, please provide a summary (abstract) and a web link to the full text.

Other information

Gender equality, diversity and zero tolerance against discrimination and harassment are important aspects of KTH's work with quality as well as core values in our organization.

For information about processing of personal data in the recruitment process please read here.

We firmly decline all contact with staffing and recruitment agencies and job ad salespersons.

Disclaimer: In case of discrepancy between the Swedish original and the English translation of the job announcement, the Swedish version takes precedence.

Type of employment Temporary position longer than 6 months
Contract type Full time
First day of employment As agreement
Salary Monthly salary according to KTH's doctoral student salary agreement
Number of positions 1
Working hours 100%
City Stockholm
County Stockholms län
Country Sweden
Reference number C-2020-0757
Contact
  • Professor Sophia Hober, sophia@kth.se
Published 14.May.2020
Last application date 25.May.2020 11:59 PM CET