PhD Fellowship in Chromatin Replication, Epigenetic Memory, and Genome Stability

University of Copenhagen Novo Nordisk Foundation Center for Protein Research

PhD Fellowship in Chromatin Replication, Epigenetic memory, and Genome stability

Novo Nordisk Foundation Center for Protein Research

Faculty of Health and Medical Sciences
University of Copenhagen

One PhD fellowship is available in the Groth group at the Novo Nordisk Foundation Center for Protein Research (NNF CPR, https://www.cpr.ku.dk/) at the University of Copenhagen. 
  
Before entering the 3-year fellowship, the successful candidate will have an initial employment as Research assistant for 1 year scheduled to start 1 April 2022 or after agreement.

Our Group

The focus of the Groth group is to elucidate how chromatin organization and function is propagated during mitotic cell division to maintain genome and epigenome stability. Our goal is to understand mechanisms that underpin epigenetic cell memory and how they impact on cell fate decisions in development and epigenetic/genetic instability in cancer. We apply innovative proteomic and genomic approaches in combination with cutting-edge cell biology, high-content imaging, chromatin biochemistry and structural biology. Our group is diverse and multidisciplinary with many scientific collaborations nationally and internationally, and we put high value on idea sharing and use Creative Problem Solving tools to develop our research projects. We also have a translational focus connected to our spin-out company Ankrin Therapeutics.

The Groth Group is part of the Protein Memory Program at NNF CPR, a multidisciplinary and international research center with a highly collaborative research environment and cutting-edge core facilities, such as genomics, proteomics, protein imaging, protein production and characterization, big data management platforms.

Project Description

The projects will address transmission of chromatin organization through DNA replication, which is key to understand epigenetic cell memory in development and disease (Stewart-Morgan et al., 2020 Nature Cell Biology). The successful candidate will join a team addressing how histones are recycled to the daughter DNA strands, using this as an entry point to elucidate how epigenome inheritance impacts gene expression in daughter cells and during development. This project builds on the recent discovery of pathways controlling recycling of parental histones by us (Petryk et al., 2018 Science) and others with links to chromatin plasticity, 3D genome organization, and genome stability. The candidate will have opportunity to learn cutting-edge genomics and proteomic approaches, genome-editing, and participate in development of super-resolution microscopy methods.

Required qualifications  

As an applicant you must have: 

  • Obtained (or expect to have obtained) a Master’s degree (equivalent to a Danish Master’s degree) in Biology, Biochemistry, Biophysics or related areas prior to the starting date 
  • Highly collaborative mindset and ability to work independently
  • Fluency in English and excellent written and oral communication skills   

Preferred qualifications 

We are especially interested in candidates with:

  • Background in chromatin biology, DNA replication, developmental biology or genome stability
  • Previous experience in next generation sequencing approaches and data analysis, protein biochemistry, genome-editing and/or super-resolution microscopy is an advantage. All necessary training will be provided to help you succeed. 

Job description 

During the first year as Research assistant, the candidate will have to formulate a PhD project, help out with research tasks and start become familiar with the research field of interest and apply for enrolment as PhD fellow.

Your key tasks as a PhD fellow at the Faculty are to: 

  • Carry through an independent research project under supervision 
  • Write scientific articles and the PhD thesis on the grounds of your research project 
  • Complete PhD courses or other equivalent education corresponding to approx. 30 ECTS points 
  • Obtain experience with teaching or other types of dissemination related to your PhD project 
  • Participate in national and international congresses and scientific meetings  
  • Stay at an external research institution, preferably abroad  

Place of employment

The employment is at CPR (www.cpr.ku.dk), a Novo Nordisk Foundation center of excellence established in 2007 and embedded in the Faculty of Health and Medical Sciences, University of Copenhagen, to promote basic and applied research on human proteins of medical relevance. The Center comprises modern laboratories, supercomputer resources and state-of-the- art facilities within protein science and genomics. CPR is an interdisciplinary international environment with English as the main language. We are located in central Copenhagen, a city with one of the highest qualities of life in the world and a vibrant and highly interactive research environment.

Terms of employment

The employment as Research assistant is full time and for 1 year. 
Salary, pension and terms of employment are in accordance with the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State. Depending on seniority, the monthly salary begins around 29,600 DKK /approx. 3.980EUR (February 2021-level) plus pension.

The employment as PhD fellow is full time and for 3 years. 
It is conditioned upon the applicant’s successful enrolment as a PhD student at the Graduate School at the Faculty of Health and Medical Sciences, University of Copenhagen, as well as a positive assessment of the 1-year research assistant position. Enrolment at the Graduate School requires submission and acceptance of an application for the specific project formulated by the applicant (for more information, please see https://healthsciences.ku.dk/phd/guidelines/).

The PhD study must be completed in accordance with The Ministerial Order on the PhD programme (2019) and the Faculty’s rules on achieving the degree. Salary, pension and terms of employment are in accordance with the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State. Depending on seniority, the monthly salary begins around 27,871 DKK /approx. 3.741 EUR (October 2021-level) plus pension.

Questions

For further information, please contact Prof. Anja Groth; e-mail anja.groth @cpr.ku.dk . For administrative information please contact the HR Center, sund-hr-cpr@sund.ku.dk.
 
Application procedure

Your application must be submitted electronically by clicking ‘Apply now’ below. The application must include the following documents in PDF format: 
-    Letter of motivation 
-    CV incl. contact details of three references and a complete list of publications, if applicable
-    Transcripts of university studies (BSc and MSc, showing individual grades). If the MSc has not yet been completed, a certified/signed copy of a recent transcript of records or a written statement from the institution or supervisor will be fine.

Application deadline: 30 Janaury 2022, 23.59pm CET

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

The further process

After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor.
The assessor makes a non-prioritized assessment of the academic qualifications and experience with respect to the above-mentioned area of research, techniques, skills and other requirements listed in the advertisement.
Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.
You can read about the recruitment process at 
https://employment.ku.dk/faculty/recruitment-process/

The applicant will be assessed according to the Ministerial Order no. 1443 of 11 December 2020 on the Appointment of Academic Staff at Universitie

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Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.

Info

Application deadline: 30-01-2022
Employment start: 01-04-2022
Working hours: Full time
Department/Location: Novo Nordisk Foundation Center for Protein Research