The Department of Biomedicine is a joint effort between the University of Basel and the University Hospitals Basel. It unites basic and clinical scientists to advance our understanding of health and disease and to develop pioneering therapies benefiting the lives of patients in areas of unmet need.
With more than 70 research groups and 800 employees, the Department of Biomedicine is the largest department at the University. We are located in the heart of Basel at 6 different locations. Be part of our future.
The Boeck lab at the Department of Biomedicine is seeking a highly motivated and driven PhD student with a strong interest in infection biology to tackle pulmonary Pseudomonas aeruginosa infections using genomic and large-scale wet lab technologies.
We are a young and dynamic team, dedicated to understand the mechanisms underlying antibiotic treatment failure of life-threatening lung infections. We have developed strategies to assess bacterial behaviour and drug susceptibility at single-cell resolution and unmet scale (e.g., assessing several 100,000 drug combinations). By combining bacterial phenotyping with CRISPR-based mutagenesis or phenogenomic analyses, we strive to reveal mechanisms driving antibiotic action and promoting bacterial clearance in patients.
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The Boeck team has recently established a method called Antimicrobial Single-Cell Testing, which allows to track millions of single cells using high-content live cell imaging. This project will adapt this technology to Pseudomonas aeruginosa and investigate whether distinct bacterial populations or single-cell behaviours (such as drug tolerance, persisters and heteroresistance) contribute to poor treatment outcomes. This project will be co-supervised by Prof. Urs Jenal (Biozentrum, Basel) and is embedded in the National Competence Centre in Research AntiResist.
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