PhD Position in Experimental Biology on Self-Organization in Multicellular Systems

Catholic University of Leuven

The work in the Jelier lab revolves around fundamental biological questions using model organisms. The research is interdisciplinary and we use both experimentation and computational modeling to advance the field. We are part of the bioengineering faculty of KU Leuven, which has a strong record of studying living systems for both applied and fundamental research. In Flanders there is an active community of C. elegans researchers, with 4 labs in Leuven. The lab is located on a beautiful campus just outside historic Leuven.

Project

In the lab we use C. elegans embryogenesis as a model to understand how cells can achieve near invariant positioning as they form a complex multicellular system. In this project you will probe the embryo with quantitative microscopy and perturb it a.o. with temporal and spatial resolution using optogenetics. In the lab we search for new relevant molecular actors in positioning, and also explore the role of mechanics, cellular stiffness, adhesion and cell polarization. The research in the group is multi-disciplinary, which in practice means that the experiments and the imaging are supported by research on expanding the molecular biology toolbox, image processing and computational modeling. 

The specific content of the PhD project will be developed collaboratively during the first months, with possible research questions related to optogenetic perturbation of cortical tension during morphogenesis or developing an innovative reverse genetic screen for robust cellular positioning. As a member of our team, the successful candidate will have the opportunity to work with state-of-the-art microscopy and computational tools, and collaborate with experts in the field.

Profile

  • Talented and enthusiastic molecular and cellular biology researcher. Master degree in biology, biotechnology, bioengineering, or similar. Good grasp of molecular and developmental biology as well as genetics with an interest in interdisciplinary work.
  • Study results should show high aptitude and research interest 
  • Good communicative skills and a collaborative attitude
  • Advanced command of English is required (knowledge of Dutch is not required)

Offer

  • A high-profile project with great scientific potential
  • Excellent scientific environment in top-ranked university, using state-of-the-art technology and methodology. We publish our research in top journals such as Bioinformatics, E-life, Molecular Biology and Evolution, Nature Genetics, PLoS genetics and Cell Systems, among others.
  • Living in the beautiful medieval university town Leuven, a lively city situated in the heart of ( Europe, 20 km from Brussels (
  • Good remuneration and benefits
  • Funding is guaranteed (4 years), but the successful candidate will be encouraged to apply for fellowships, such as those by the Flemish funding agency (FWO). 
  • Applicants should submit a detailed CV and a cover letter expressing your motivation and interest in the position. 
  • Contact details for two referees who can provide academic references (no letters). 

Interested?

For further information or to apply you can contact Rob Jelier: Rob.Jelier@kuleuven.be
You can apply for this job no later than May 31, 2023 via the
KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR@kuleuven.be.
  • Employment percentage: Voltijds
  • Location: Leuven
  • Apply before: May 31, 2023
  • Tags: Bio-ingenieurswetenschappen
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