PhD Position in Medicine

University Medical Center Freiburg Clinic of Medicine

The Clinic of Medicine II, University Medical Center Freiburg, is looking for a

PhD student (m/f/d)

We focus on translational research in the field of tumor immune escape in Hepatocellular carcinoma. Our results contribute to a better understanding of tumor-immune cell interactions with implications for therapeutic strategies.
Job description:
The aim of this project is to comprehensively study the role of Wnt/β-catenin tumor cell signaling for activation and functionality of the tumor immune microenvironment in hepatocellular carcinoma using patient-derived 3D model systems and high-dimensional immune cell profiling. Your work will give insights into the potential of Wnt/β-catenin signaling as a targetable candidate pathway to improve tumor susceptibility to immunotherapy for the continuously rising number of patients with hepatocellular carcinoma.

We offer:

  • a translational project in a clinically relevant setting with the possibility to implement your own ideas
  • working in a dedicated interdisciplinary team of biologists and physicians on exciting research topics
  • possible participation in a graduate program
  • a unique network of excellent partners for continuous support in development of your scientific profile
  • a good working atmosphere in modern laboratories with cutting-edge equipment
  • buddy system for new doctoral researchers
  • participation in a wide range of further training opportunities and participation in (inter-)national conferences
  • salaries are based on the German academic standards (TV-L, 65 %) with attractive employee benefits, e.g. JobTicket UKF
  • an annual additional payment
  • 30 days of vacation

Your work includes but is not limited to:

  • autonomous processing of research tasks related to immune escape in hepatocellular carcinoma
  • working with 3D ex vivo models including tumor spheroids and organoids
  • application of state-of-the-art and cutting-edge methods of cell and molecular biology including immunohistochemistry, imaging mass cytometry, high dimensional FACS
  • establishing of new methods to elaborate on subsequent research questions
  • working with infectious sample material (S3** lab)
  • presentation of results on regular lab and (inter-)national conferences
  • supervision of students


  • we are looking for a highly motivated and enthusiastic individual who enjoys translational scientific work in an interdisciplinary and international team
  • graduation (M. Sc.) in biology, molecular medicine or related subjects preferentially with focus on oncology and/or immunology
  • strong interest in translational research, human immunology and oncology
  • distinct working autonomy combined with a high capacity for teamwork
  • a careful and focused working habit
  • enjoy scientific work
  • awareness of careful documentation
  • ability to work independently and as a part of an international team
  • communication skills in English
  • knowledge in presentation skills

If you are interested, please submit your application in German or English (including CV, a motivation letter and contact details of two references).

University Medical Center Freiburg
Clinic of Medicine II
(Translational EXperimental IMmunology lab)
Hugstetter Str. 55, 79106 Freiburg

For further information please contact:

Dr. Catrin Tauber
General information: Salary is assigned according to a pay scale. Unless prevented by operational or legal reasons, full-time positions are generally open to those wishing to job share. Where two candidates are equally suitable for a post, severely disabled candidates are given priority. Employment decisions are made by the Personnel Department.