PhD Scholarship in Development of Novel Chemical Probes to assist Target Deconvolution in Phenotypic Drug Discovery

Monash University Institute of Pharmaceutical Sciences

PhD Scholarship - Development of Novel Chemical Probes to assist Target Deconvolution in Phenotypic Drug Discovery

Job No.: 618125

Location: Parkville campus 

Employment Type: Full time

Duration: 3-year fixed-term appointment

Remuneration:  Scholarship award provides a stipend of AUD$29,500 per annum (tax free)

We are looking for a highly motivated, passionate and competitive candidate for a fully-funded PhD positions in medicinal chemistry and proteomics. The successful candidate will join an international team working in an area of high interest for drug discovery. The students will be mainly based at the Monash Institute of Pharmaceutical Sciences (MIPS) (Monash University, Parkville campus), with the opportunity to also work at Newcastle University (UK).

About this position:

This position forms part of a collaborative program with the Newcastle University (UK). Monash University and Newcastle University are both world top-150 research-intensive Universities with major strengths in translational biomedical research. The PhD student will conduct drug discovery research that aligns with the research interest of both universities.

The reconnection of the scientific community with phenotypic drug discovery has created exciting new possibilities to develop therapies for diseases with highly complex biology. It promises to revolutionise fields such as neurodegenerative disease and regenerative medicine, where the development of new drugs has consistently proved elusive. Arguably, the greatest challenge in readopting the phenotypic drug discovery approach exists in establishing a crucial chain of translatability between phenotype and benefit to patients in the clinic. Excellent quality chemical probes and chemistry-based target deconvolution techniques will be a crucial part of this process. Therefore, the aim of the project is to develop novel innovative chemical probes to assist target deconvolution methods in phenotypic drug discovery.

International Collaborations

The successful applicant will be enrolled at Monash University and spend majority of the time at the Monash Institute of Pharmaceutical Sciences (MIPS) under the supervision of Dr Manuela Jörg and Associate Professor Darren Creek. This project is performed in collaboration with Dr Kate Madden, a group leader at Newcastle University in the UK. The student will be encouraged to make use of the incredible opportunity to spend up to 12 months at Newcastle University in the UK.

The candidate’s attributes:

Applications are invited from outstanding and enthusiastic graduates with a relevant background in synthetic organic chemistry or medicinal chemistry.

Domestic students are preferred due to the uncertainty around international travel restrictions due to COVID-19.

We are looking students of high scholarly calibre with:

• A First Class Honours degree, Masters degree or equivalent

• Analytical thinking, data analysis and critical problem solving skills

• Excellent time management skills and ability to work independently

• Applicants with publications will be highly regarded

• Fluency in written and oral English

Informal inquiries are strongly encouraged and should be directed to Dr Manuela Jörg. Include a CV, transcripts and cover letter


Dr Manuela Jörg,

Closing Date 

Sunday 18 April 2021, 11:55 AEDT