Post Doc in Early Human Embryo Stem Cell Models

Catholic University of Leuven Department of Development and Regeneration

To decipher the gene regulatory logic of pre-implantation and early post-implantation human embryo development. The Pasque Lab is a molecular and cellular biology research group based at KU Leuven, University of Leuven, Department of Development and Regeneration, Belgium. Our research focuses on understanding epigenetic reprogramming in cells, development and diseases. We are interested in understanding how the identity of one type of somatic cell can be reprogrammed to another type. We want to know how modifications of DNA, chromatin and RNA help to maintain cell identity, are reversed and re-established during cell fate reprogramming as well as how they may become eroded in diseases. We use a variety of cell fate reprogramming systems including somatic cell reprogramming to induced pluripotent (iPS) cells, mammalian pluripotent stem cells and embryos. We employ molecular, biochemical and cellular approaches as well as modern transcriptomic and epigenomic approaches, combined with genetic and epigenetic editing to dissect the molecular mechanisms of cell fate control. Understanding epigenetic reprogramming could help us to better direct cell fate for regenerative medicine, to understand the molecular basis of embryo development and hallmarks of several human diseases including cancer.

Responsibilities

The Laboratory of Cellular Reprogramming and Epigenetic Regulation at the KU Leuven is seeking a highly motivated postdoc to study cell fate specification in human pre-implantation and early post-implantation embryogenesis. Your goal will be to identify factors and the gene regulatory logic underlying the induction of human trophoblast cell fates. To this end, you will use human pre-implantation embryos and imaging, stem cell-based embryo models (2D, 3D), single-cell transcriptomics plus chromatin accessibility assays, genome engineering and computational biology approaches. You will explore the functional significance of candidate regulators of human trophoblast development recently identified in the Pasque lab.

Profile

  • PhD degree in Life Sciences, Bioinformatics, Bioscience Engineering or related.
  • Experience with cell culture, molecular biology, transcriptomics, epigenomics, early mammalian embryogenesis, human pluripotent stem cells is a plus

Offer

  • Postdoc position in a young international team at the KU Leuven
  • The KU Leuven (University of Leuven) is located in the city of Leuven, a historic, international, dynamic and lively city at the center of Belgium and Europe. The KU Leuven is currently placed amongst the best universities in the world by the Times Higher Education and has been deemed as Europe's most innovative university for 3 years in a row.
  • Modern facilities, beyond state-of-the-art technologies and infrastructure
  • You will join the recently founded KU Leuven Single-Cell Omics Institute
  • The position is immediately available
  • Stimulating and collegial research environment
  • You will join a young and motivated international team with an outstanding network of collaborations
  • Exceptional healthcare benefits

Interested?

For more information please contact Mrs. Christina Vochten, tel.: +32 16 33 02 95, mail: christina.vochten@kuleuven.be.

You can apply for this job no later than October 14, 2021 via the
KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR@kuleuven.be.
  • Employment percentage: Voltijds
  • Location: Leuven
  • Apply before: October 14, 2021
  • Tags: Ontwikkeling en Regeneratie