Post Doc in NMR-Based Structural Biology

University of Gothenburg Department of Chemistry and Molecular Biology

PostDoc in NMR-Based Structural Biology

Ref PAR 2021/871

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The University of Gothenburg tackles society’s challenges with diverse knowledge. 53 500 students and 6 500 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.

Research and graduate education at the department of chemistry and molecular biology comprises a wide scientific field from the atomic and molecular levels all the way through cells to intact organisms. Much of the phenomena studied here impact on our natural environment and living systems. We participate in undergraduate programs in chemistry, molecular biology, medicinal chemistry, biology, marine sciences, and pharmacy.

The group of Björn Burmann uses state of the art NMR-spectroscopy to study large molecular complexes underlying basic cellular functions at the atomic level in combination with other structural biology methods and biophysical characterization. Our group will use E.coli based expression for specific isotope-labeling suited to study large proteins and their respective molecular complexes playing an integral role for bacterial and/or mmitochondrial transcription.

Job assignments

The research project aims at advancing the molecular understanding of the function and regulation of transcription processes at the atomic level by advanced NMR-spectroscopy. Malfunction of these fundamental machineries leads to errors in the respective cells, which subsequently can provide the foundation for cell death in bacteria. Specifically, you will study (1) the molecular mechanisms by which the RNA-polymerase works (2) how post-translational modifications influence their function, and (3) how the RNAP is regulated by auxiliary factors. To achieve this goal, you will use a plethora of techniques ranging from basic biochemistry to advanced structural biology methods (not restricted to NMR-spectroscopy only, as it is planned to also apply X-Ray crystallography or cryo-electron microscopy whenever indicated by our data) and biophysical characterization. Methods in microbiologymolecular biology, bioinformatics and biochemistry will also be used. We are looking for a colleague, that is highly motivated, scientifically independent and creative, and capable of contributing to a team environment.

Qualifications

To qualify as a PostDoc, the applicant must have completed a Swedish doctoral degree or must have a foreign degree corresponding to a Swedish doctoral degree. A have a strong background in biochemistry, biophysics, and/or NMR spectroscopy. You must have knowledge in recombinant protein expression and purification of relevant proteins (nucleic acid binding proteins), knowledge in solution NMR methods (e.g. assignment, protein dynamics, data analysis, knowledge in sample preparation (isotope labelling, methyl-labelling), detailed knowledge in additional biophysical and structural biology techniques (ITC, BLI, SEC-MALLS, EM, X-Ray). You also have experience in the work with mitochondrial proteins is considered avantagous as well as previous work on related protein systems. Previous work with nucleic acids and nucleic acid binding proteins, e.g. expression and purification and/or functional characterization for structural studies, will be considered an advantage. 

Employment

The employment is a fixed term during 2 years, fulltime at the Department of Chemistry and Molecular Biology.

For further information regarding the position

Regarding the position, please contact
Björn Burmann, Associate Professor, +46(0)31 786 3923 bjorn.marcus.burmann@gu.se

Unions

Union representatives at the University of Gothenburg:
https://www.gu.se/en/about-the-university/work-at-the-university-of-gothenburg/how-to-apply

Information for International Applicants

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https://www.gu.se/en/about-the-university/welcome-services
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How to apply

In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline. The selection of candidates is made on the basis of the qualifications registered in the application. Your application must include:

A letter with motivationmed motivering till varför du söker tjänsten
CV including your research publications
Copy of your PhD
Two references (name, phone number, relation)

Closing date:2021-08-15

The University of Gothenburg promotes equal opportunities, equality and diversity.

Salary is determined on an individual basis.

Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.

In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.

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