Our lab is specifically interested in the genetics of familial hypercholesterolemia and other dyslipidemias. LDL-cholesterol levels as a key risk factor of atherosclerosis development have a strong genetic background. It has been shown that individuals with monogenic hypercholesterolemia are at higher risk of premature cardiovascular disease than individuals with polygenic hypercholesterolemia, and those are at higher risk than individuals with lifestyle-related high cholesterol levels. Thus, the determination of the individual genetic risk of hypercholesterolemia might help establish the individual risk of cardiovascular disease development and might facilitate a personalized approach to therapy. A specific effort is being made to identify a genetic cause for the severe FH phenotype in patients who tested negative after standard genetic analysis. We are particularly focusing on polygenic factors and polygenic risk scores, the role of which has not been sufficiently defined and elucidated yet. We are also studying the importance of molecular genetic diagnostics in familial hypercholesterolemia neonatal/paediatric screening.
The postdoctoral position will be part of the more significant NPO project LX22NPO5104 named "National Institute for Metabolic and Cardiovascular Research", funded by the Ministry of education, youth and sports (RRF). We are currently looking for a motivated, enthusiastic, and independent postdoc with a background in molecular genetics, molecular biology, medical biology, biochemistry, genetic epidemiology, metabolic or cardiovascular medicine, or a related field to help us uncover the molecular principles of polygenic versus monogenic determination of hypercholesterolemia and/or atherosclerosis, as well as the role of molecular diagnostics in personalized medicine.
The successful candidate should:
MU offers the opportunity to get:
Workplace: University campus, Kamenice 5, 625 00 Brno, the Czech Republic
Job contract: A fixed-term until November 2025, with the possibility of extension for additional projects
Workload: 40 hours per week
Start of work: as soon as possible, based on mutual agreement
The applicant shall submit:
How to apply?
Please use the "E-Application" link below. After submitting your application, you will receive an automatic confirmation of acceptance via email.
For more information, contact prof. MUDr. Tomáš Freiberger, PhD. by e-mail: tomas.freiberger@cktch.cz or Mgr. Tatiana Kováčová, Ph.D. at tatiana.kovacova@cktch.cz
A review of applications will commence immediately after the deadline. Short-listed candidates will be invited for interview within one month of the deadline.
Further information about: