Postdoc Position in Mitochondrial Adaptations to Exercise in a Cancer Context

University of Copenhagen Department of Biomedical Sciences

Postdoc in mitochondrial adaptations to exercise in a cancer context at the Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen

We are looking for a highly motivated and dynamic researcher for a 2-3-year position to commence 1 October 2021 or as soon as possible hereafter to work on the project entitled: Harnessing mitochondrial adaptations to exercise to promote functional restoration of muscle in cancer.

Our research

Our research in the Molecular Metabolism in Cancer and Ageing Group focuses on delineating the molecular causes of muscle wasting and associated metabolic dysfunctions. We strive to identify mechanisms that, at the molecular level, regulate muscle mass, function, and metabolism. With muscle wasting and insulin resistance being central features of cancer cachexia, ageing, and diabetes, we are uncovering the pathology of these conditions at the molecular level by studying cells, mice, and humans. In particular, we focus on how muscle wasting and metabolic abnormalities can be improved or even reversed by exercise training.

For more information about the activity of the group, please visit the Molecular Metabolism in Cancer and Ageing group here https://bmi.ku.dk/english/research/endocrinology-and-metabolism/molecular-metabolism-in-cancer-and-ageing/

Information on the department can be found at https://bmi.ku.dk/english/

Your job

As a postdoctoral candidate, you will have the opportunity to work on an interesting and challenging project that will profit from your enthusiasm, creativity and willingness to implement new methodology. We have identified two mitochondrial proteins responsive to exercise training and you will be working with transgenic mouse models as well as human sample material from patients with cancer cachexia to understand their regulation and role in mitochondrial function and pathophysiology.

Essential experience and skills:

  • PhD in Molecular Biology or related sciences
  • Excellent scientific track record relative to career stage
  • Experience in skeletal muscle mitochondrial regulation and function, exercise adaptations, and skills in microscopy.
  • Experience in a wide range of molecular biology techniques like RT-qPCR, cloning, western blotting etc.
  • Experience with animal work with accreditation to conduct research in animals (EU Function ABD/FELASA C or similar)
  • Capacity to efficiently work in a multidisciplinary and ambitious team to reach common goals
  • Outstanding time-management skills and capacity for effective and realistic planning
  • Excellent English communication skills, both written and oral

Desirable experience and skills:

  • Knowledge of cancer cachexia and experience with preclinical models
  • Knowledge of mitochondrial DNA and RNA regulation and RNA stabilizing proteins
  • Experience with muscle cell culture incl. primary human cells

Place of employment

The place of employment is at the Department of Biomedical Sciences, Panum Institute, University of Copenhagen. We offer creative and stimulating working conditions in a dynamic and international research environment with local and international collaborators. Our research facilities include modern human, animal, and cell laboratories and a microscopy core facility.

Terms of employment

The employment as a postdoc is a full time and fixed-term position for 2-3 years. Starting date is 1 October 2021 or after agreement.

Salary, pension and terms of employment will be in accordance with the agreement between the Ministry of Finance and AC (Danish Confederation of Professional Associations). Depending on qualifications, a supplement may be negotiated

Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years. 

The position is covered by the “Memorandum on Job Structure for Academic Staff at the Universities” of January 2020.

The University of Copenhagen International Staff Mobility office offers support and assistance to all international researchers on all issues related to moving to and settling in Denmark. Read more at www.ism.ku.dk.

Questions

For further questions about the job description and qualifications position please contact associate professor Lykke Sylow, 20955250, E-mail: Lykkesylow@sund.ku.dk  

For questions regarding the recruitment procedure, please contact sund-hr-bmi@sund.ku.dk

Application procedure

Your online application must be submitted in English by clicking ‘Apply now’ below. Furthermore, your application must include the following documents/attachments – all in PDF format:

1. Motivated letter of application (max. one page).

2. CV incl. education, work/research experience, language skills, contact details for at least three references, and other skills relevant for the position.

3. A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do.

4. List of publications.

Application deadline:  15 May 2021, 23.59pm CET

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

The further process

After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at https://employment.ku.dk/faculty/recruitment-process/

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

Interviews are expected to be held in week 23 to 25.

University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone.

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Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.

Contact

Lykke Sylow
E-mail: lshansen@nexs.ku.dk

Info

Application deadline: 15-05-2021
Employment start: 01-10-2021
Working hours: Full time
Department/Location: Department of Biomedical Sciences