Postdoctoral Fellowship in Co-Transcriptional Processing

University of Copenhagen Department of Cellular and Molecular Medicine

Postdoctoral Fellowship in Co-Transcriptional Processing in The Gregersen Group at the Department of Cellular and Molecular Medicine

Faculty of Health and Medical Sciences
University of Copenhagen

We are offering a postdoctoral position to a talented and highly motivated researcher interested in investigating how RNA-binding proteins regulate co-transcriptional processing. The successful candidate will be employed in the newly established Gregersen group at the Institute of Cellular and Molecular Medicine (ICMM) at the Faculty of Health and Medical Sciences, University of Copenhagen.

About the group and the Istitute

The newly started Gregersen group will be located at the ICMM from February 2021. The research group is funded by a Hallas-Møller Emerging Investigator grant from the Novo Nordisk Foundation.

The group focuses on various aspects of co-transcriptional regulation primarily mediated by RNA-binding proteins. Recent papers include: Gregersen et al. 2019 Cell [PMID: 31104839] and Gregersen et al. 2020 Nature Protocols [PMID: 31915390].

We use a wide range of experimental approaches including cell biology, next-generation sequencing (RNA-seq, TTchem-seq, mNET-seq, ChIP-seq, CLIP etc.) as well as molecular biology techniques (western blots, immunoprecipitations, peptide pull-outs and proteomics) to decipher the molecular mechanisms of factors involved in co-transcriptional regulation and the composition of transcription complexes in human cells.

The Gregersen group represents cutting-edge interdisciplinary research and training, and will be located within the ICMM in the Panum Institute. We will have access to state-of-the-art facilities for cell engineering, next-generation sequencing, flow cytometry, and mass spectrometry.

For more information about our research please see: https://icmm.ku.dk/english/research-groups/gregersen-group/.

Project description

The work will be focused on elucidating the mechanisms of RNA polymerase associated factors. The main focus will be on RNA-binding proteins directly interacting with actively elongating RNA polymerase complexes with the aim to understand how these factors couple RNA-binding and/or processing to transcriptional regulation and co-transcriptional processing of the newly made RNA transcript. The project involves generation of human cell lines using CRISPR/Cas technologies combined with profiling of transcription using a combination of RNA-seq approaches (RNA-seq, TTchem-seq, etc.) as well as proteomics investigation of RNAPII complexes. The role of the candidate will primarily be to perform experiments in the laboratory, analyse and interpret data, scientific publication, as well as attend scientific seminars and conferences. Some teaching at the undergraduate level of the Medical School is to be expected.

Your profile

  • You have a PhD in Biochemistry, Molecular Cell Biology or similar
  • Keen interest in transcription and/or RNA biology
  • You possess research experience and publication records in relevant fields, ideally with prior experience in transcription, gene expression or RNA biology
  • Previous experience with high-throughput sequencing is an advantage but not a requirement
  • Proficient communication skills and ability to work in teams
  • Excellent English skills written and spoken

Place of employment

The place of employment is at the Department of Cellular and Molecular Medicine (ICMM), University of Copenhagen. ICMM offers a creative and ambitious scientific environment, with many different nationalities represented. ICMM aims to produce research with high international impact focusing on the functional cell, its genetic components and molecular cellular mechanisms in a medical context. ICMM currently comprises five research programs, three high profile Research Centers as well as a number of international research groups. The scientists at ICMM are involved in high quality research based undergraduate and graduate teaching programs at the University of Copenhagen. More information can be found at www.icmm.ku.dk

Terms of employment

The employment as postdoctoral researcher is a full time and fixed-term position for 3 years with the possibility of extension. Starting date is 1 March 2021 or after agreement.

Salary, pension and terms of employment will be in accordance with the agreement between the Ministry of Finance and AC (Danish Confederation of Professional Associations). Currently, the monthly salary starts at 34,650 DKK/ approx. 4,650 Euro (April 2020-level). Depending on qualifications, a supplement may be negotiated. The employer will pay an additional 17.1 % to your pension fund.

Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.

The position is covered by the “Memorandum on Job Structure for Academic Staff at the Universities” of 11 December 2019.

Questions

For further information please contact: Lea H. Gregersen, ICMM, (Gregersen email)

Foreign applicants may find this link useful: www.ism.ku.dk (International Staff Mobility).

Application procedure

Your online application must be submitted in English by clicking ‘Apply now’ below. Furthermore, your application must include the following documents/attachments – all in PDF format:

  1. Motivated letter of application (max. one page)
  2. CV incl. education, work/research experience, language skills and other skills relevant for the position
  3. A certified/signed copy of PhD certificate. If the PhD is not completed, a written statement from the supervisor will do.
  4. List of publications
  5. Teaching portfolio if applicable

Application deadline: 7 December 2020, 23.59pm CET.

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

The further process

After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor.

The assessor makes a non-prioritized assessment of the academic qualifications and experience with respect to the above-mentioned area of research, techniques, skills and other requirements listed in the advertisement.

Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at https://employment.ku.dk/faculty/recruitment-process/.

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone.

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Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.

Contact

Lea Haarup Gregersen
E-mail: leag@sund.ku.dk

Info

Application deadline: 07-12-2020
Employment start: 01-03-2021
Working hours: Full time
Department/Location: Department of Cellular and Molecular Medicine
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