Postdoctoral Researcher in Neurobiology

Technical University of Munich

Wissenschaftliches Personal, Postdoctoral researcher Neurobiology

Postdoctoral researcher (f/m/d) in neurobiology and neurodegeneration research Description of research: The laboratory of Prof. Dr. Stefan Lichtenthaler studies the molecular mechanisms underlying neurodegenerative diseases, with a focus on cell surface proteases, such as ADAM10 and BACE1, as well as the role of microglia in Alzheimer’s disease pathology. Specifically, the lab uses proteomic, biochemical and molecular and cell biological techniques as well as animal models. More information is found on our webpage: www.dzne.de/lichtenthaler We offer excellent projects and training in neurodegeneration and protease research. We are an international and interdisciplinary team, are part of several larger research consortia (e.g. DFG-funded excellence cluster SyNergy in Munich and a European JPND project) and are located in the German Center for Neurodegenerative Diseases in Munich-Großhadern. Your tasks: Recently, several Alzheimer risk genes (e.g. TREM2) have been discovered which are selectively expressed in microglia, the brain-resident immune cells. As part of an international JPND research consortium, you will elucidate the mechanism and function of different microglia-related Alzheimer risk gene variants. To achieve this goal, you will perform research on human induced pluripotent stem cell (iPSC)-derived microglia and human monocyte-derived microglia (MDMi). Furthermore, you will work with acutely isolated microglia using magnetic activated cell sorting (MACS). Functional and mechanistic studies with the different cell types will include phagocytosis and cytokine assays as well as biochemical assays (e.g. ELISA, Western blots, proteomics). Qualifications and experience: You have a PhD in neurobiology, molecular biology or a related field and experience with cell culture and iPSC differentiation, demonstrated by publications. You are familiar with biochemical assays such as Western blots and ELISA. Experience with primary murine cell culture and/or mouse experiments is an advantage. You do not need to have previous knowledge about Alzheimer’s disease or neurodegeneration. You are creative, highly motivated and you are able to work independently. Essential qualities include fluency in English and a strong team spirit. Appointment is full time and will be initially for two years with the possibility of renewal. We give priority to severely disabled applicants with essentially equal qualifications.

Description of research:

The laboratory of Prof. Dr. Stefan Lichtenthaler studies the molecular mechanisms underlying neurodegenerative diseases, with a focus on cell surface proteases, such as ADAM10 and BACE1, as well as the role of microglia in Alzheimer’s disease pathology. Specifically, the lab uses proteomic, biochemic al and molecular and cell biological techniques as well as animal models. More information is found on our webpage: www.dzne.de/lichtenthaler

We offer excellent projects and training in neurodegeneration and protease research. We are an international and interdisciplinary team, are part of several larger research consortia (e.g. DFG-funded excellence cluster SyNergy in Munich and a European JPND project) and are located in the German Center for Neurodegenerative Diseases in Munich-Großhadern.

Your tasks:
Recently, several Alzheimer risk genes (e.g. TREM2) have been discovered which are selectively expressed in microglia, the brain-resident immune cells. As part of an international JPND research consortium, you will elucidate the mechanism and function of different microglia-related Alzheimer risk gene variants. To achieve this goal, you will perform research on human induced pluripotent stem cell (iPSC)-derived microglia and human monocyte-derived microglia (MDMi). Furthermore, you will work with acutely isolated microglia using magnetic activated cell sorting (MACS). Functional and mechanistic studies with the different cell types will include phagocytosis and cytokine assays as well as biochemical assays (e.g. ELISA, Western blots, proteomics).

Qualifications and experience:

You have a PhD in neurobiology, molecular biology or a related field and experience with cell culture and iPSC differentiation, demonstrated by publications. You are familiar with biochemical assays such as Western blots and ELISA. Experience with primary murine cell culture and/or mouse experiments is an advantage. You do not need to have previous knowledge about Alzheimer’s disease or neurodegeneration. You are creative, highly motivated and you are able to work independently. Essential qualities include fluency in English and a strong team spirit.

Appointment is full time and will be initially for two years with the possibility of renewal. We give priority to severely disabled applicants with essentially equal qualifications.

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Kontakt: anke.moeller@dzne.de

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