Postdoctoral Researcher in Translational Cancer Research

University of Helsinki

A POSTDOCTORAL POSITION is available at the Translational Cancer Medicine research group led by Academy professor Kari Alitalo, in the Faculty of Medicine in the University of Helsinki, Finland. The Alitalo group is located in Biomedicum Helsinki of the Academic Medical Center Helsinki (Meilahti campus), which ranks at the top 10 medical campuses in Europe and among the top 50 globally. Alitalo leads the Translational Cancer Medicine Program and the Wihuri Research Institute, which both provide a multidisciplinary research environment for basic and translational research with state-of-the-art facilities, cutting-edge technologies and synergistic expertise of several research groups.

Research project:

The position is funded by the European Research Council (ERC) Horizon 2020 program ”BrainDrain, Translational implications of the discovery of brain- draining lymphatics”. In 2010, 800 billion Euros was spent on brain diseases in Europe and the cost is expected to increase due to the aging population. The aim of the BrainDrain is to alleviate this disease burden and reassess current concepts about cerebrovascular dynamics, fluid drainage and cellular trafficking in physiological conditions and in Alzheimer’s disease and neuroinflammation models in mice and in postmortem tissues in humans.

The main objectives concern neurovascular interactions in CNS diseases, with questions related to 1) The development and properties of meningeal lymphatic vessels and how they are formed and maintained. 2) Blood brain barrier and the clearance of macromolecules and protein aggregates in mouse models of Alzheimer’s disease, and in mice that lack the newly discovered meningeal lymphatic drainage system. 3) Examine if growth factors modulate CNS vasculature, especially if expansion of lymphatic vessels alleviates the parenchymal accumulation of neurotoxic molecules and brain disease pathogenesis and brain damage after traumatic brain injury.

Key requirements:

We are looking for a highly motivated postdoctoral research scientists with a strong enthusiasm towards science. A successful candidate should have a PhD degree and strong background in molecular and cell biology, cellular biochemistry, genetics, or other related discipline. Previous experience with biomedical research is considered an advantage and expertise in bioinformatics and mouse models is beneficial. Excellent communication skills (in English), and technical and organizational abilities are expected.

Research in the laboratory led by Academy Professor Kari Alitalo focuses on Vascular biology related to human diseases, discovery of new disease-related functions of vascular endothelial growth factors, angiopoietins, angiogenesis and lymphangiogenesis. The goal is to use this knowledge for establishment of preclinical models for more effective targeted therapies on these diseases.

The position is available as soon as the best applicant is available. The project allows a fixed-term position until July 2022, after which transfer to a related grant or to a position in the Wihuri Research Institute (wri.fi) is possible. A trial period of six months will be applied.

The initial starting salary is at the level 5 for teaching and research personnel according to the salary system of the Finnish universities. In addition, a salary component will be paid based on personal performance, with an overall starting salary to approximately 3200 EUR per month, which is increased based on the qualifications and previous relevant research experience of the candidate.

Please submit your application via the University of Helsinki Recruitment System by clicking the ‘Apply for the position’ button below. Internal applicants (i.e. current employees of the University of Helsinki) should submit their applications through the SAP HR portal. If you need support with the recruitment system, please contact recruitment (at) helsinki.fi.

Please attach the following documents to your application as a single PDF file:
• Cover letter (maximum 1 page) that details your past experience and motivation for applying to the post.
• CV (including publications)
• Contact details of at least two referees

The deadline for applications is May 16th 2021. Interviews will be conducted either in person or online.

For more information on the position, please contact Academy professor Kari Alitalo, kari.alitalo (at) helsinki.fi. For additional information on the recruitment process, you may also contact HR Specialist Päivi Sinisalo, paivi.sinisalo (at) helsinki.fi.

About the University of Helsinki

The University of Helsinki (UH), founded in 1640, is a vibrant scientific community of 40,000 students and researchers. It is one of the leading multidisciplinary research universities and ranks among the top 100 international universities in the world. It is currently investing heavily in life sciences research. UH offers comprehensive services to its employees, including occupational health care and health insurance, sports facilities, and opportunities for professional development.

Together with the Helsinki University Hospital (HUS) and the Helsinki Institute of Life Sciences (HiLIFE), the Faculty of Medicine, University of Helsinki, constitutes the Academic Medical Center Helsinki (AMCH). This medical center has been very successful in international comparisons, ranking among the top 10 medical campuses in Europe and among the top 50 globally.

https://www.helsinki.fi/en/researchgroups/translational-cancer-biology

Due date

16.05.2021 23:59 EEST

 
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