Research Assistant in Therapeutic Immunology and Infectious Disease

University of Cambridge

The University of Cambridge is seeking to appoint a Research Assistant. The project is part of a collaborative project investigating the immunological basis for the onset of type 1 diabetes (T1D) in collaboration with The Environmental Determinants of Diabetes in the Young (TEDDY) consortium. TEDDY is a prospective cohort study aiming to determine the genetic and environmental interactions causing T1D. We are undertaking single cell transcriptomic, proteomic and immune receptor repertoire (VDJseq) analysis of longitudinal samples from a nested case:control cohort of TEDDY samples taken from infants prior to islet autoantibody seroconversion, T1D onset or both. The project involves prior flow sorting enrichment of immune populations from frozen, viable TEDDY samples followed by the generation of single cell total gene expression data alongside enriched library sequencing to quantitate sequence-tagged antibodies (CITEseq) identifying both surface protein expression and islet antigen-specific CD4+ and CD8+ T cells using sequence-tagged dextramers. We will use information from these analyses to inform functional studies of immune dysfunction in T1D and to develop tests or, ultimately, treatments that allow us to predict and prevent T1D onset.

The successful applicant will be primarily based in the Cambridge Centre for Therapeutic Immunology and Infectious Disease, based in the Jeffrey Cheah Biomedical Centre, University of Cambridge, Department of Medicine. There is a minimum requirement of a Bachelor's degree in biological science with appropriate experience in a molecular biology laboratory environment (or equivalent qualification and/or experience). Familiarity with data processing and analysis including basic bioinformatics is preferred but not essential.

The post is full-time, on a Fixed-term basis; The funds for this post are available for 1 years in the first instance.

Informal enquiries should be directed to Dr Eoin McKinney -

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Cloing Date: 19th December 2020

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Please quote reference RC24796 on your application and in any correspondence about this vacancy.

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