Research Associate in Chemical Biology and Imaging

Imperial College London Department of Chemistry

Job summary

We are seeking an outstanding Research Associate in Chemical Biology and Imaging to contribute to a Leverhulme Trust funded project across the Barnard and Kuimova groups in the Department of Chemistry. The project is based on the development of fluorescent dyes termed molecular rotors to study intracellular protein-protein interactions. The project is funded for a period of two years, with a possible one-year extension. The start date is from...

Job listing information

  • Reference NAT00961
  • Date posted 20 July 2021
  • Closing date 16 August 2021

Key information about the role

  • Location White City Campus (map)
  • Position type Full time, fixed term
  • Salary £40,858 – £44,434 plus benefits
  • Department Department of Chemistry
  • Category Researcher / Non Clinical Researcher

Job description

Job summary

We are seeking an outstanding Research Associate in Chemical Biology and Imaging to contribute to a Leverhulme Trust funded project across the Barnard and Kuimova groups in the Department of Chemistry. The project is based on the development of fluorescent dyes termed molecular rotors to study intracellular protein-protein interactions. The project is funded for a period of two years, with a possible one-year extension. The start date is from 1st November 2021 with some flexibility.

Duties and responsibilities

This project will involve the development of peptide-rotor conjugates targeting therapeutically relevant protein-protein interactions and the establishment of reliable assays for the characterisation of the in vitro and in cellulo protein binding using fluorescence lifetime imaging microscopy (FLIM). The successful candidate will be expected to take a leading role in probe design and synthesis and the characterisation of their cellular binding profile using similar approaches to those published by the Kuimova group (ACS Nano 2018, 12, 4398; Biomaterials, 2017, 139, 195; Nat. Comm. 2021, 12, 162) alongside coordinating collaborative aspects of the project.

Essential requirements

You will have (or be near completion of) a PhD in chemistry or chemical biology, or a closely related field, or an equivalent level of professional qualifications and experience, with a strong desire to progress in your career at a world leading research institution.

Essential criteria include a strong track record in chemical biology, preferably demonstrated by first author publications in leading research journals. You must be an expert user of optical instrumentation and have experience in fluorescence spectroscopy or microscopy, as well as multi-step organic synthesis and small molecule characterisation. You will have demonstrable creativity and the ability to work effectively in an efficient and independent manner and achieve clear objectives within a multidisciplinary team. Additional training and support can be provided on key techniques where necessary. Prior experience in any of the following would be highly advantageous: cell culture, molecular biology or peptide synthesis, ultrafast lasers, fluorescence microscopy; Fluorescence Lifetime Imaging Microscopy (FLIM), time resolved optical spectroscopy.

Further information

This is a full-time, fixed term position for two years (with possibility of extension) and will be based at the White City Campus. The start date is from 1st November 2021 with some flexibility.

*Candidates who have not yet been officially awarded their PhD will be appointed as Research Assistant within the salary range of £36,045 - £39,183 per annum.

Anticipated interview date: 09/09/2021

The successful candidate will become part of the world-leading Chemistry department at Imperial College London as part of the Institute of Chemical Biology. In 2018, our department moved to a new building within the College’s White City Campus which provides new state-of-the-art facilities allowing us to significantly expand our research efforts through extended collaboration both within the wider College and externally.

We particularly encourage applications from women and underrepresented ethnic minority groups.

Informal enquiries to:

Dr Anna Barnard: a.barnard@imperial.ac.uk, http://www.imperial.ac.uk/the-barnard-group

Dr Marina Kuimova: m.kuimova@imperial.ac.uk, https://www.imperial.ac.uk/people/m.kuimova

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level.

http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research

We are committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment for all. We therefore encourage candidates to apply irrespective of age, disability, marriage or civil partnership status, pregnancy or maternity, race, religion and belief, gender identity, sex, or sexual orientation. We are an Athena SWAN Silver Award winner, a Disability Confident Leader and a Stonewall Diversity Champion