Research Associate in Epigenetics

Imperial College London Department of Brain Sciences

Job summary

The UK Dementia Research Institute (UK DRI) is seeking an outstanding postdoctoral Research Associate interested in taking on a challenging role with considerable scope for independent scientific achievement and personal growth.  The UK DRI at Imperial has been established to address a medical research area of the highest importance and future impact. As one of seven national centres of excellence embedded in major UK universities, we intend...

Job listing information

  • Reference MED02114
  • Date posted 12 November 2020
  • Closing date 15 December 2020

Key information about the role

  • Location White City Campus (map)
  • Position type Full time, fixed term
  • Salary £40,215 – £47,579 plus benefits
  • Department Department of Brain Sciences
  • Category Researcher / Non Clinical Researcher

Job description

Job summary

The UK Dementia Research Institute (UK DRI) is seeking an outstanding postdoctoral Research Associate interested in taking on a challenging role with considerable scope for independent scientific achievement and personal growth. 

The UK DRI at Imperial has been established to address a medical research area of the highest importance and future impact. As one of seven national centres of excellence embedded in major UK universities, we intend to transform the diagnosis, treatment and care of people with dementias.  The Medical Research Council and charity partners the Alzheimer's Society and Alzheimer’s Research UK invested £290m in fulfilment of the ambition identified in the Prime Minister's 2020 Challenge on Dementia.

The research group of Dr Nathan Skene addresses key questions about the mechanisms of neurodegenerative disease.  In a series of recent publications in Nature Genetics, the lab has demonstrated that single cell RNA-seq data from mice can be used to identify the cell types associated with genetic risk factors for neurodegenerative disease. We aim to develop single cell epigenetic techniques, such as ATAC-seq and CUT&TAG, to enhance our ability to map intergenic loci to cell type specific features.

Duties and responsibilities

You will be expected to help to define specific research programmes within this remit and undertake these in conjunction with colleagues in multi-disciplinary teams.  Considerable independence is expected, with anticipation of a growing role in leadership of the research.  In addition, you will be expected to submit publications to refereed journals and to join in attracting external research funding.

Essential requirements

You will have prior experience working with genomic/epigenetics methods. A background in neurobiology or immunology would be beneficial but not essential. Experience with flow cytometry, neuroanatomy, and cell culture are also relevant to the project. Familiarity with bioinformatics, R programming, version control and workflow languages would be advantageous.

The ideal candidate will be ambitious, with the passion to tackle big problems and a readiness to try out high-risk, high-payoff projects. The ideal candidate will be passionate about tackling big problems with data-driven genetically focused strategies. You should show initiative and independent thinking, possess excellent communication skills and be able to work effectively as part of a team.

There will be opportunities for supervision of students. Experience in other teaching roles, including lecturing, will be enabled as part of the broad range of career development opportunities that Imperial College makes available to its post-doctoral research staff.

Further information

The contract is offered full time, initially for a fixed term until 31 March 2023 with potential for extension for a further five years.

Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £35,477 - £38,566 per annum.

Applicants are strongly encouraged to contact Dr Nathan Skene for informal discussion about the role at n.skene@imperial.ac.uk  

For more information about the UK DRI at Imperial, please visit:

http://www.imperial.ac.uk/dementia-research-institute

Dr Skene’s research website: https://www.neurogenomics.co.uk/

The UK Dementia Research Institute: https://ukdri.ac.uk/

Should you have queries about applying for the role, please contact Dr Jennifer Podesta j.podesta@imperial.ac.uk

For technical issues when applying online please email recruitment@imperial.ac.uk

Committed to equality and valuing diversity, we are also an Athena SWAN Silver Award winner, a Stonewall Diversity Champion, a Disability Confident Employer and are working in partnership with GIRES to promote respect for trans people.

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level. http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research