Research Associate in Heart and Lung

Imperial College London National Heart and Lung Institute

Job summary

We are seeking a dynamic and independent post-doctoral researcher (maternity cover) with experience in airway epithelial cell biology to support a multicentre study funded by a Wellcome Trust Strategic Award “Pulmonary epithelial barrier and immunological functions at birth and in early life – key determinants of the development of asthma?” (Breathing Together) which investigates the molecular mechanisms underlying development of wheeze...

Job listing information

  • Reference MED01921
  • Date posted 21 July 2020
  • Closing date 19 August 2020

Key information about the role

  • Location South Kensington Campus (map)
  • Position type Full time, fixed term
  • Salary £40,215 – £47,579 plus benefits
  • Department National Heart & Lung Institute
  • Category Researcher / Non Clinical Researcher

Job description

Job summary

We are seeking a dynamic and independent post-doctoral researcher (maternity cover) with experience in airway epithelial cell biology to support a multicentre study funded by a Wellcome Trust Strategic Award “Pulmonary epithelial barrier and immunological functions at birth and in early life – key determinants of the development of asthma?” (Breathing Together) which investigates the molecular mechanisms underlying development of wheeze in preschool children.

You will join a multidisciplinary research team run by Professors Lloyd & Saglani within the Inflammation, Repair & Development Section. The work involves the collection and in vitro culture of epithelial cells collected as part of the multicentre project, and development of in vitro systems to examine epithelial cell function. You will determine how cells respond to stimulation with different agents such as allergens and pathogens and assess the contribution of various mediators to the development of innate and adaptive immune responses. You will use systems well established in the group but will have the freedom to develop novel systems to investigate the hypothesis.

Duties and responsibilities

  • To be responsible for experimental work utilizing air-liquid interface cultures of epithelial cells collected from different sites within the consortium
  • To develop novel systems to examine cell function and interaction with the immune system.
  • To conduct cytokine assays, histological analysis, immunocytochemistry, in situ hybridisation, flow cytometry, in vitro culture of T cells and pulmonary cells as required
  • To maintain highly organised and accurate records of experimental work.
  • To conduct data analysis, ensuring the validity and reliability of data at all times
  • To undertake appropriate administrative tasks
  • Any other duties commensurate with the grade of the post as directed by line manager as well as Head of Group/Section.

Essential requirements

    • PhD degree in Biological Sciences, ideally with a high immunology content, or equivalent industrial or commercial experience
    • Experience at post-doctoral level in laboratory research in inflammation biology and immunology with proven publications
    • Experience in culture and analysis of primary epithelial cells
    • In depth knowledge of inflammation biology and immunology,
    • In depth knowledge of epithelial cells and mucosa immunology

Further information

This is a full time, fixed-term maternity cover position available immediately for 12 months (with possibility of an extension).

*Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £35,477 - £38,566 per annum.

Informal enquiries can be made directly to Professors Clare Lloyd and Sejal Saglani. email: c.lloyd@imperial.ac.uk, s.saglani@imperial.ac.uk

For technical queries when applying online, please contact recruitment@imperial.ac.uk

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

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