Research Associate in Molecular and Cell Biology

University of Cambridge

The Biffi Laboratory at the CRUK Cambridge Institute (part of the University of Cambridge) is seeking to hire a bright, creative and motivated Research Associate (post-doctoral level), with strong skills in molecular and cell biology, tissue culture and mouse work to join a team working on studying and targeting the tumour microenvironment of pancreatic cancer.

The team combines ex vivo human and murine pancreatic tumour organoid/fibroblast co-cultures with murine in vivo models to study and target the interactions between pancreatic cancer cells and the surrounding microenvironment. Common techniques used in the laboratory are generation of orthotopic transplantation models of pancreatic cancer, flow cytometry and sorting, single-cell and bulk RNA-sequencing, multiplexed immunohistochemistry, RNA in situ hybridization, microscopy, drug and CRISPR strategies in both organoids and fibroblasts, pre-clinical studies in genetically engineered mouse models of pancreatic cancer, and analysis of human pancreatic tissues.

The CRUK Cambridge Institute provides cutting-edge scientific infrastructure and expertise. The successful candidate will have access to our world class core facilities and laboratory resources.

The prospective candidate will lead a developing project in the lab to characterize the roles of distinct fibroblast subtypes in pancreatic cancer and inflammation using new in vivo and in vitro models. It is expected that, as a post-doctoral member of the group, the successful candidate will have a significant input over the direction of its own project, and will contribute with its original and innovative ideas.

The candidates should have or be about to receive a PhD in a relevant discipline. They should have a strong background in molecular biology and cell biology, with prior knowledge of tissue culture techniques, flow cytometry, microscopy and mouse work. Prior expertise in biology and models of pancreatic cancer is highly desirable. Expertise in data analysis (e.g. analysis of bulk and single-cell RNA sequencing) is desirable. Candidates are expected to work effectively as part of a diverse and inclusive team, to be highly collaborative, good communicators and creative thinkers, able to find solutions to problems and contribute intellectually to other projects.

For up-to-date information about the research group, please see our websites at: https://www.cruk.cam.ac.uk/research-groups/biffi-group https://biffilab.wordpress.com/blog-2/

Fixed-term: The funds for this post are available for 3 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Closing Date: 11th April 2021

Please quote reference SW25988 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.