Research Associate in Molecular Mechanisms of Cell Death

University of Cambridge

The 'Molecular Mechanisms of Cell Death' research group, led by Prof. Marion MacFarlane, is focussed on investigating cell death pathways that are regulated in response to members of the TNF cytokine family and agents that trigger mitochondrial-dependent cell death, with a specific emphasis on mechanisms that regulate activation of cell death signalling complexes.

We have pioneered the reconstitution of cell death signalling complexes, including the Death-Inducing Signalling Complex (DISC), with the aim of determining the overall 3D architecture of these large macromolecular assemblies and ultimately their structure. This project offers the exciting opportunity to integrate biochemical & molecular and cell biology approaches to enable characterisation/obtain novel insights on the regulation of multiprotein signalling complexes that direct cell fate.

We are now looking to appoint a postdoctoral Research Associate to join our team. The post will be ideal for a candidate with experience in applying and developing state-of-the-art technologies/methods for determining the roles and modes of interaction between proteins that regulate the activity of multiprotein signalling complexes, in particular those that direct cell death/survival. However, talented candidates with a strong background in cell death signalling who are keen to apply state-of-the-art technologies/methods for analysis of key regulators of cell death and the discovery of novel biology are encouraged to apply. Additionally, the post-holder will be expected to develop their own projects, in line with lab strategic interests.

The MRC Toxicology Unit is an internationally renowned institution focussed on the delivery of field-changing mechanistic insights into toxicology and disease. The Unit is equipped with state-of-the-art facilities including super resolution microscopy, mass spectrometry, Cryo-EM, advanced flow-cytometry and offers excellent opportunities for postdoctoral development. The Unit will physically relocate to the Gleeson Building, Central Cambridge in Nov 2020.

Applicants must hold a PhD in a relevant discipline such as Biochemistry or molecular and cell biology. The ability to work both independently and as part of a team, together with excellent communication and critical thinking skills are also essential. Further information on the Toxicology Unit can be found at (https://www.mrc-tox.cam.ac.uk)

Relevant publications:

  • Horn et al. Caspase-10 Negatively Regulates Caspase-8-Mediated Cell Death, Switching the Response to CD95L in Favor of NF-KB Activation and Cell Survival. Cell Reports, 2017.
  • Hughes et al. Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate. Molecular Cell, 2016.
  • Dickens et al. A death effector domain chain DISC model reveals a crucial role for caspase-8 chain assembly in mediating apoptotic cell death. Molecular Cell, 2012.

Key Collaborative Publications:

  • Tenev et al. Molecular Cell, 2011, 43:432-448; Feoktistova et al Molecular Cell, 2011, 43:449-463.

Fixed-term: The funds for this post are available for three years in the first instance.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries are invited and can be directed to Marion MacFarlane at mm2312@mrc-tox.cam.ac.uk.

If you have any queries regarding the application process please contact Bronwen Chamberlain at bc535@mrc-tox.cam.ac.uk

Please quote reference PU24426 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.