Research Associate in Single Molecule Fluorescence Imaging of Protein Aggregates

University of Cambridge Department of Chemistry

Fixed-term: The funds for this post are available for 2 years in the first instance.

A postdoctoral position is available in the group of Sir David Klenerman FMedSCi FRS in the Department of Chemistry. The group is developing ways to detect and characterize protein aggregates associated with neurodegenerative disease and cancer using single molecule fluorescence based methods. For an overview of the groups recent work see our recent review (Imaging individual protein aggregates to follow aggregation and determine the role of aggregates in neurodegenerative disease, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics,1867, 870-878 (2019)).

The project is to develop new ways to image protein aggregates in human samples at 20 nm resolution. Chemically modified PET ligands will be used for DNA paint imaging of aggregates, allowing their binding affinity to different size and types of aggregates to be determined. The same method will then be adapted to screen for new ligands that bind aggregates using competition assays.

Applicants should have experience in single molecule fluorescence or super-resolution imaging and a PhD (or be about to obtain) in biophysics. Experience with automated bespoke instrumentation is desirable. Applicants should have an interest in applying physical method to biomedical problems but previouse experience of working on neurodegenerative disease is not needed.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload your Curriculum Vitae (CV), a cover letter, and a full list of your publications in the upload section of the online application. If you upload any additional documents that have not been requested, we will not be able to consider these as part of your application.

For queries regarding applying online for this post, please contact Becky Jupe (e-mail: rej43@cam.ac.uk).

Please quote reference MA24317 on your application and in any correspondence about this vacancy.

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