Research Associate in Synthetic Inorganic Chemistry and Biomedical Imaging

Imperial College London Department of Chemistry

Job summary

A Research Associate position in Synthetic Inorganic Chemistry and Biomedical Imaging is available within the Chemistry Department at Imperial College, London, based at the new White City campus. You will join the group of Prof. Nick Long (https://www.imperial.ac.uk/people/n.long) building on their successful track record in applied synthetic inorganic chemistry and in particular, the development of functionalised biomedical imaging probes...

Job listing information

  • Reference NAT00853
  • Date posted 1 February 2021
  • Closing date 1 March 2021

Key information about the role

  • Location White City Campus (map)
  • Position type Full time, fixed term
  • Salary £40,858 – £48,340 plus benefits
  • Department Department of Chemistry
  • Category Researcher / Non Clinical Researcher

Job description

Job summary

A Research Associate position in Synthetic Inorganic Chemistry and Biomedical Imaging is available within the Chemistry Department at Imperial College, London, based at the new White City campus. You will join the group of Prof. Nick Long (https://www.imperial.ac.uk/people/n.long) building on their successful track record in applied synthetic inorganic chemistry and in particular, the development of functionalised biomedical imaging probes e.g.  MRI-fluorescence: (Dalton Trans., 2020, 4732; Theranostics, 2020, 2659; Nanotheranostics, 2020, 184; PNAS, 2019, 26614); Positron Emission Tomography: (Dalton Trans., 2020, 1097; J. Nucl. Med., 2019, 1750; Chem. Sci., 2019, 5603).

The project forms part of an exciting large-scale initiative with the University of Hong Kong and Peking University.  With funding from the Innovation and Technology Commission, the Laboratory for Synthetic Chemistry and Chemical Biology has been created at the University of Hong Kong.  Imperial College is a lead collaborator with the Laboratory and several research programmes, including this one led by Prof Long, will be housed in the Department of Chemistry, Imperial College (other PIs are Profs Tate, Vilar and Fuchter) but connected to the Laboratory.  There will be opportunities for collaboration, travel and research placements in Hong Kong.

The research aims to develop a range of new biomedical imaging probes focussing on diseases such as diabetes, cancer and Alzheimer’s.  The project will have two facets (i) to explore the use of dual-modal imaging probes (e.g. a combination of MRI, NIR fluorescence and PET/SPECT) towards therapeutic zinc and other metal sensing models and (ii) designing new lipophilic cationic molecules for imaging of the mitochondria – this could again feature dual-modal techniques or targeted single modalities such as PET (e.g. 68Ga, 18F radiolabelling). The research will involve a range of synthetic inorganic and organic chemistry, alongside biomedical imaging and analysis.

Duties and responsibilities

We are looking for someone with a range of synthetic chemistry (inorganic and organic) experience and skills in imaging sciences.  This role will encompass varied responsibilities, including work on a wide range of collaborative projects.  You will develop new chemistry and chelators and use them to develop dual-modal imaging agents, metal sensors and radiometal-based mitochondria imaging agents. In addition, you will perform preclinical research in biomedical imaging, ideally including in vitro and in vivo biological studies and one or more imaging modalities (e.g. optical, MRI, PET and SPECT, CT). This work will involve collaborations with research groups across Imperial College and the University of Hong Kong and drive the development and translation of bioimaging probes in a range of disease types.

Essential requirements

    • A PhD degree (or equivalent) in Chemistry
    • Experience and knowledge of synthetic inorganic and organic chemistry
    • Experience and knowledge of imaging chemistry
    • Experience and knowledge of metal coordination chemistry and chelator design
    • Experience of one of more chemical/biological aspects of molecular imaging e.g. radiochemistry, magnetic resonance imaging, cancer biology etc.
    • A track record of publications appropriate to their career path
    • Excellent verbal and written communication skills and the ability to deal with a wide range of people

Further information

This position is fixed-term and full time for 24 months, with the possibility of extension.

*Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £36,045 - £39,183 per annum

The Department of Chemistry proudly holds an Athena SWAN Gold Award and strives to provide a working environment where all our staff feel fully supported to flourish and excel. The Department of Chemistry is committed to promoting the wide range of Family Friendly policies and associated initiatives offered by the College.

For informal enquiries about this position please contact Prof. Nicholas Long (n.long@imperial.ac.uk)

For technical issues when applying online please email recruitment@imperial.ac.uk

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level.

http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research

Imperial College is committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment. We are an Athena SWAN Silver award winner, a Stonewall Diversity Champion, a Disability Confident Employer and work in partnership with GIRES to promote respect for trans people.