Research Fellow in Biochemistry/Biophysics

University of Leeds School of Molecular and Cellular Biology

Research Fellow in Biochemistry/Biophysics

Are you looking to apply your skills in Structural Biology and Imaging to gain a new molecular understanding of the mechanism of amyloid formation and help to develop new routes to combat amyloid disease?

We are looking for an outstanding postdoctoral research fellow to join our interdisciplinary team that is investigating how proteins aggregate into amyloid fibrils, including the link between disease-relevant mutations and post-translational modifications and fibril structure. Funded by Wellcome, you will use a wide range of biochemical and biophysical methods to map the early protein-protein interactions in amyloid formation and to discover new routes to prevent or control these interactions. In addition, you will create and characterise amyloid fibrils formed in vitro under different conditions and purify amyloid from patient samples and, working alongside members of the group with expertise in cryoEM, solve their structures in atomic detail, so as to better understand the origins of fibril polymorphism and its role in disease.

You will be based in the laboratory of Professor and work closely with other members of the amyloid team (funded by BBSRC, the Royal Society, MRC and Wellcome). You should have a PhD (or be close to completing one) in Structural Biology, Chemical Biology, Biochemistry, Biophysics or a related discipline, with extensive experience of using biochemical and biophysical methods to elucidate biological mechanisms. 

Further information about the project and our recent publications are available within the additional information document.

To explore the post further or for any queries you may have, please contact: 

, Astbury Professor of Biophysics

Tel: +44 (0)113 343 3170 | Email:

Location: Leeds - Main Campus
Faculty/Service: Faculty of Biological Sciences
School/Institute: School of Molecular & Cellular Biology / Astbury Centre for Structural Molecular Biology
Category: Research
Grade: Grade 7
Salary: £34,304 to £40,927 p.a.
Working Time: 100% - We will consider flexible working arrangements
Post Type: Full Time
Contract Type: Fixed Term (for 24 months due to external funding)
Release Date: Monday 06 June 2022
Closing Date: Thursday 21 July 2022
Reference: FBSAS1054
Downloads: Additional Information