Researcher in Biochemistry

Syracuse University Chemistry

Researcher in Biochemistry

Posting Details

Job # 076990
Job Title Postdoctoral Researcher - Biochemistry
Location Syracuse, NY
Pay Range $58,500
FLSA Status Exempt
Hours
As determined by principal investigator
Job Type Full-time
Rank Post Doc
Campus Syracuse, NY
Unionized Position Code Not Applicable
Job Description
The Castañeda lab uses a variety of biochemical and biophysical methods and techniques to uncover fundamental aspects of how proteins undergo liquid-liquid phase separation.We aim to determine how protein quality control mechanisms interface with membraneless organelle assembly and disassembly, particularly in how cells respond to stress.
We currently seek a researcher with background in biophysics and/or biochemistry to examine the physicochemical properties that determine physiological phase separation using molecular approaches such as NMR spectroscopy, small angle scattering, and single molecule FRET.
Our lab has multiple projects that focus on the role of liquid-liquid phase separation as it relates to the structure and function of ubiquitin-binding shuttle proteins.We are looking for driven and excited scientists to join our growing research group.The candidate will enter an openly collaborative environment with excellent colleagues/mentors and biophysical resources.
Our lab works with many other research labs at Syracuse University in the Departments of Biology and Chemistry as well as throughout the country, including the University of Michigan and St. Jude Children’s Research Hospital.The aims of the project are to examine how protein quality control components (including the proteasome, polyubiquitin chains, etc.) regulate the assembly and disassembly of biomolecular condensates, and to elucidate the underlying mechanisms of how domain-domain interactions alter and modulate phase separation.
The researcher will join an interdisciplinary environment with opportunities to learn new techniques and develop new research directions and ideas.Specific research goals will be discussed and agreed with the principal investigator.
Qualifications
  • Have a PhD or nearing completion of a PhD in biophysics or related area (e.g. biochemistry)
  • Possess skills in molecular cloning, protein expression, and protein purification.
  • Have excellent oral and written communication skills, pays attention to detail, is eager to present ideas and results at group meetings and conferences, and is highly organized with data management.
Job Specific Qualifications
  • Excited to lead new experiments to quantify phase transitions (e.g. UV/Vis spectrophotometric assays, light scattering, microscopy).
  • Willing to learn or have experience with biomolecular NMR spectroscopy of folded proteins or intrinsically disordered proteins.
  • Skilled or interested in using and developing other biophysical methods such as light scattering, small angle scattering, single molecule FRET.
Responsibilities
    • Lead and be a team player in designing and executing biochemical and biophysical experiments, small angle scattering experiments, and other biophysical techniques to probe the structure, dynamics, and function of proteins involved in protein homeostasis and protein quality control pathways.
    • Clone, express and purify proteins from bacterial and other model systems
    • Develop and codify quantitative methods to analyze protein interactions and contributions to modulating phase separation and condensate formation/dissolution (including modeling, scripting in Python and R, Matlab, Mathematica, etc.)
    • Write detailed experimental protocols and keep meticulous lab notebooks
    • Communicate results clearly both in oral and written formats including talks, poster sessions, and journal articles.
    • Mentor graduate and undergraduate students, purchase supplies, maintain instrumentation, participate in literature discussions, and contribute to writing proposals.
    • Other duties as assigned.

 


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Quick Link https://www.sujobopps.com/postings/98708
Job Posting Date 04/21/2023
Application Deadline  
Open Until Filled Yes
Priority Consideration  
Job Category Faculty
Message to Applicants  

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